Doxycyclineの基礎的・臨床的研究

抄録

1. Determination of MIC of DOTC, TC and other antibiotics against 26 strains of Staphylococcus aureus isolated from sputa during the period from February to April 1968 has revealed that the values for DOTC were 1/2 to 1/4 of those for TC, and also the MIC of DOTC was lower than 25 mcg/ml with all strains examined.
2. The determination of tissue concentration of DOTC has revealed that the highest peak concentration was observed first in kidney followed by liver, lung and blood in this order. Higher level of the antibiotic is maintained for long period especially in the lung.
3. In our chemotherapeutic experiment with mice infected with pathogenic Staphylococcus (Small strain), definitely better results were obtained in DOTC treated animals than in TC treated ones.
4. Treatments with DOTC were effective in 15 patients, mostly with chronic infection o f air way, as far as the pathogen was sensitive to the antibiotic. It is remarkable that the administration of 100 mg of the antibiotic given on alternate days, differently from the usual administration schedule, to patients with chronic respiratory infections was proved to be quite effective.