CLINICAL AND EXPERIMENTAL EVALUATION OF DOXYCYCLINE(DOTC) IN STAPHYLOCOCCAL INFECTIO N S
1969 Volume 17 Issue 2 Pages 269-272
Details
1969 Volume 17 Issue 2 Pages 269-272
Minimum inhibitory concentrations (MIC) of 52 strains of Staphylococcus aureus from surgical infections for DOTC were distributed from 50 to 0. 09 mcg/ml. Forty-four strains (90. 4 %) were inhibited to grow at 0. 39, 0. 19 and 0. 09 mcg/ml. The maximal blood levels of DOTC of 100 and 200 mg orally administered in adult were 1. 4 and 2. 6 mcg/ml respectively at 6th hour, showing the longer-acting tendency than the other tetracyclines.
There were no effects of DOTC on e xperimental staphylococcal subcutaneous infections which were performed by inoculation of 107 and 108 order Staphylococcus aureus on rabbit ears. All the strains isolated from abscesses on 7th day had the same MIC (0. 09 mcg/ml) as those on the inoculation.
Response to DOTC therapy for the patients with surgical infections was considered excellent in 15 cases out of 17, by 200 mg/day on the first day and 100 mg/day on the latter days.
Five cases showed alimentary tract disorders as a side effect of oral DOTC administration The symptoms were abdominal pain, nausea, vomiting, loose bowel and diarrhea, and none of these appeared after taking a cup of water with DOTC capsules.
