1969 Volume 17 Issue 2 Pages 273-278
1) The maximum blood concentration was 3. 47 mcg/ml in average of 3 cases at 3 hours after single oral administration of 200 mg of DOTC. The blood concentration was still 1. 38 mcg/m1 even at 24 hours after the administration of the antibiotic. Subsequent daily dosage of 100 mg gave the value of 2. 98 and 2. 20 mcg/m1 at 12 hours after the first and second administration, respectively. In average of 3 cases, 16. 5% of orally administered 200 mg of the drug was excreted in urine within 24 hours.
2) The concentration of the drug excreted into pus following oral administration of 200 mg of the drug reached the maximum value somewhat dalayed that of blood level, followed by a parallel reduction with the latter.
3) While Streptococcus isolated from lesions showed 2 to 4 times higher drug sensitivity to DOTC than to TC, no such difference was found with E. coli.
4) DOTC was given to 32 cases of surgical infec tions and effective in 71%. As the main side effect, gastric disturbances such as nausea, vomiting, or abdominal pain were noted in 6 cases.
