STUDIES ON THE HIGH MOLECULAR SUBSTANCES POSSESSING CHEMOTHERAPEUTIC ACTIVITY. VI

The Effect of Antivirin on Poliovirus Ribonucleic Acid and Protein Synthesis in Infected Cells

Abstract

Antivirin depresses the development of infectious poliovirus particles, the incorporation of H³-uridine into viral specific RNA and the formation of infectious RNA in the early time of the multiplicationstep, even in the presence of actinomycin D.
Antivirin, however, does not depress the incorporation of H³-uridine into cellular RNA. The inhibitory effect of A antivirin on the incorporation of H³-valin into viral specific protein is lower than that on viral specific RNA-synthesis.