STUDIES ON THE HIGH MOLECULAR SUBSTANCES POSSESSING CHEMOTHERAPEUTIC ACTIVITY. VII

Antivirin-E, an Antiviral Substance found in Ascites of Tumor bearing Mice

Abstract

Antivirin-E, an antiviral substance found in ascites of Ehrlich ascites tumor bearing mice, was investigated.
Antivirin-E was inhibitory on the intracellular multiplication of polio (types 1, 2 and 3) and vaccinia viruses. The site of action of antivirin-E was considered to be the inhibition of the replicative step of the intracellular multiplication of susceptible virus. The antiviral activity was inactivated by proteolytic enzyme treatment, but not with both RNase and DNase. Antivirin Fs activity was unstable in the pH range of acidic and alkali sites, and was decreased to 50% by heating at 57°C for 60 minutes.