STUDIES ON THE SYNERGISTIC ACTION OF AMINOBENZYLPENICILLIN AND ANMDE THYLCHLOROPHENYLISOXAZ OLYLP E N I C ILLIN. III
In vivo synergism, absorption and excretion
1969 Volume 17 Issue 6 Pages 986-992
Details
1969 Volume 17 Issue 6 Pages 986-992
The enhanced therapeutic activity in vivo was provided in combination (2: 1 of 1: 1) of AB-PC with MCI-PC for treatment of experimental infection of mice, when challenged with a clinically isol ated strain of E. coli which was resistant to AB-PC and MCI-PC.
In the treatment of mice infected with Staph. aure us T-5 which was highly resistant to AB-PC but sensitive to MCI-PC, the similar tendency was also obtained in this combination.
When AB-PC and MCI-PC were administered intramuscularly to ani mals, blood, urinary and biliary levels of both penicillins were not influenced by their combination ratio. Furthermore, both peniillins were detected in the urine from rabbit, administered AB-PC and MIC-PC, bythin layer chromatography and agar-gel electrophoresis.
