STUDIES ON THE COMBINED CHEMOTHERAPY OF MALIGNANT TUMORS: BASED ON THE ADMINISTRATION OF FIBROBLAST-INHIBITING AGENTS

Abstract

For the purpose of arresting both stromal connective tissue and parenchymal cancer cells, the combined therapy with fibroblast-inhibiting agents(Chloroquine and Phytonadione), anti-cancer agent(Mitomycin C or Cyclophosphamide) and Prednisolone was studied. The results were as follows.
In experimental studies of metastatic lung tumors of YOSHIDA sarcoma and EHRL ICH ascites cancer, the combined therapy was more effective than each single administration. In clinical application, considerable therapeutic effects of this combined therapy were obtained in various human cancers, particularly in lung cancers and malignant lymphomas. It is very interesting that transient prevention of aggravation was observed in the majority of these cancer patients.