STUDIES ON THE ANTIBIOTIC COMBINATION
With Special Reference to the Combination of Acetyl-Spiramycin with Chloramphenicol or Tetracycline
1970 Volume 18 Issue 2 Pages 140-144
Details
1970 Volume 18 Issue 2 Pages 140-144
The synergistic or antagonistic actions between acetyl-spiramycin (AC-SPM) and chloramphenicol (CP) or tetracycline (TC) were investigated in vitro in respect of combined use of antibiotics and small clinical trials were performed. The results obtained were as follows.
1. The drug susceptibility test of Staphylococcus aureus strains carried out by agar dilution plate method showed synergistic action in about a half of 42 strains tested. In case of gram-negative bacilli, one antibiotic had no influence upon another, and vice versa. These facts were similarly observed on both combinations of AC-SPM with CP or TC.
2. The effect of such antibiotic combination upon growth curve of two strains of Staphylococcus aureus in broth was not so obvious comparing with the action of each single antibiotic.
3. Four cases were treated with the combination of AC-SPM and CP, being administered with tablet containing 125 mg of each drug. Eight tablets were administered orally in 4 divided doses for 5 days and all of them showed good effectiveness.
