気道感染を伴なう慢性閉塞性肺疾患に対する新化学療法剤Thiamphenicolの臨床効果

喀疾の細菌学的検査と関連して

抄録

Thiamphenicol was given orally in a dose of 1.5g daily for 7-14days to 16 patients of chronic obstructive pulmonary diseases aggravated by infection. These patients were subjected to the tests. for pulmonary function, erythrosedimentation rate, expectoration etc. before and after the treatment with thiamphenicol.
Either increase of 30% or more in the spirogram per sencond or normalization in the erythrosedimentation rate were regarded as an improvement of diseases. Seven cases out of them were im proved in both finding, 3 cases were improved in either of the findings.
The results of the sensitivity test of the pathogenic bacteria in sputum revealed that 4 cases were very sensitive (+++), 4 case sensitive (++), 4 case slightly sensitive (+) while the rest 6 cases were resistant. The above results did not quite coincide with the clinical results.
There were two cases who developed such side effects as slight gastro-intestinal disturbance, diarrhea and appetite depression but such side effects desappeared after discontinuation of the therapy with thiamphenicol.
Thiamphenicol was founded to be effective for the treatment of infectious obstructive pulmonary diseases with slight side effects.