1970 Volume 18 Issue 8 Pages 1038-1045
1) The drug sensitivity test for the isolated strains from the samples of the patients was conducted by the disk diffusion method, using 3 kinds of concentration in each disk. As the result of the test, CEX was superior to CER, CET and AB-PC as far as gram negative bacilli are concerned.
2) The concentration of CEX in the organs of rats after the administration was high in the kidney and the liver, moderate in the blood, and low in the lungs.
3) In human beings, the maximum concentration in the blood was 20 mcg/ml in 1 hour after 500 mg of CEX administration, the effective concentration in the blood may be retained for 4 hours. This concentration was 5 times higher than that of AB-PC. The recovery rate of CEX in the urine was 88% within 4 hours after administration. It can be said that the absorption and excretion of CEX are smooth.
4) The application of CEX to the infectious disease of the respiratory organs is considered to be effective as long as the pathogess are gram positive cocci (Pneumococcus, Staphylococcus aureus, etc.). However, it is not so effective for chronic bronchitis, bronchopneumonia, bronchiectasis of which “Hemophilus infiuenzae” takes a part.
5) Any ill effects such as rash, allergic reaction, damage to the liver or the kidney, gastrointestinal distress could not be observed at all.
