THE SYNERGISTIC ACTION OF SPIRAMYCIN AND CHLORAMPHENICOL INSTAPHYLOCOCCUS AUREUS

Abstract

It was found that erythromycin is an active inducer for macrolide (Mac) resistance in inducibleresistant strains of S. aureus, but not spiramycin (SP). In this respect, SP is found to be useful in chemotherapy for Mac inducible-resistant strains.
The synergistic action of SP and CP (chloramphenicol) was demonstrated in vitro test for Staphylococcal strains.
Induction for Mac resistance did not take place when CP was added to the induction mixture. Addition of CP also lowered the mutation rate to Mac high resistance in Mac inducible-resistant strains.