Abstract
Experiments were carried out using rabbits. In order to study the influence of α-chymotrypsin to the concentration of penicillin in tissue, α-chymotrypsin and penicillin G (PC-G) were administered concomitantly and the concentration of PC-G into the experimental operative wound was measured with certain time interval. Histological study was also performed.
As far as the PC-G concentration in serum is concerned, it increased only when α-chymotrypsin was administered simultaneously with a dose of 60 to 250 times of usual human dose. Simultaneous administration seemed to be effective to increase the PC-G concentration in the inflammatory focus.
PC-G concentration in the inflammatory foci surrounding the operative wound, where there is circulatory impairment due to tissue damage, did not increase remarkably. However, histopathological study revealed the tendency to accelerate the healing process of inflammatory foci. Lymphatic vessels surrounding the inflammatory foci was proved to be dilated. It may play a certain role.
As α-chymotrypsin is considered to promote an infectious process, when it is administered in early stage of infection, it is essentially neccessary to administer appropriate antibiotics simultaneously, when α-chymotrypsin is used in this stage.
