Abstract
Up to this time it was said that thiamphenicol, one of relatives of chloramphenicol, hereafter TP, was almost not metabolized in comparison with chloramphenicol. But it was found by means of chemical assay that its metabolites were relatively more excreted in the guinea pig bile. Accordingly, after TP were administered to guinea pig and rabbit, their bile and urine were examined by thin layer chromatography, β glucuronidase and synthesized derivatives of TP, its probable metabolites. As the result, its glucuronide and deacylated TP were found as its metabolites.
