Abstract
Basic studies on the combination of several antibiotics and proteolytic enzymes with special reference to proctase were carried out and the following results were obtained.
1. The growth of Staphylococcus aureus under the existence of some antibiotics was slighty more inhibited by adding proctase in initial stage.
2. The sensitivity of Staphylococcus aureus against some antibiotics was increased two to eight folds on the plate containing enzymes in few instances.
3. The inhibiting effect against abscess formation in the experimental Staphylococcus aureus infection was somewhat superior in the group with pre-treatment of various enzymes than the one without treatment.
4. The organ level of antibiotic in mice pre-treated with proctase was not so different from the control ones.
