1971 Volume 19 Issue 3 Pages 180-183
On nafcillin, a new antibiotic in Japan, we performed laboratory and clinical studies in the orthopedic infectious disease.
With 53 strains of Staph. aureus isolated from the patients of osteomyelitis, the sensitivities to nafcillin (NF-PC), MCI-PC and PC-G were measured by the plate dilution method.
The MIC values of NF-PC were 0.10 to 1.59 mcg/ml (peak 0.39 mcg/ml) and NF-PC was sensible to PC-G resistant strains.
A 500 mg intramuscular dose developed a peak serum level at 1 hr. (7.9 mcg/mg) and a peak synovial fluid level at 4 hr. (1.90 mcg/ml).
Ten cases of chronic osteomyelitis and 3 cases of subcutaneous infection were treated with NF-PC.
The results were excellent in 3 cases, good in 7 cases and no effect in 3 cases that were chronic osteomyelitis.
Side effect was not found in all cases.
