POST-OPERATIVE LOCAL INJECTION THERAPY OF ROLITETRACYCLINE IN ORTHOPAEDIC FIELD

Abstract

Rolitetracycline (PRM-TC) was used by this author in local wounds after many kinds of orthopaedic surgeries. It was applied by injection into the wounds soon after operations while the patients were still under anesthesia, and every case has already received the injection of the new drugs before surgery. There were 87 cases whose ages ranged from 3 to 83.
There were sufficiently good results with minimum doses of the new antibiotics in pre- and post-operative administrations ; for example, the average doses of the new drugs were 1.4 ampoules by injection and the other antibiotics were administered per os only 4.8 days in addition.
No serious side-effects were found among all of the 87 cases, and no symptoms of post-operative infection were observed except one patient who was suffering from osteomyelitis. In particular, 15 cases had no antibiotics except local injection of PRM-TC.
At the aseptic operation, and the like the antibiotics were injected 90 minutes before surgery, when the blood concentration reached its peak, and just at that time operations could be performed. In addition, as soon as the operation was finished PRM-TC was injected locally into the wound, and the use of the new antibiotics was not needed thereafter. PRM-TC is a highly commendable drug, if used for the above purpose with the method above mentioned.