ON THE IN VITRO ANTIBACTERIAL ACTIVITY OF NITROIMIDAZOLE THIADIAZOLE, A NEW SYNTHETIC ANTIBIOTIC

Abstract

A study on in vitro antibacterial activities of nitroimidazole thiadiazole, a new synthetic antibiotic, was carried out using 11 species of bacteria. As controls, 10 kinds of known antibiotics were used.
This drug completely inhibited, at the concentration of less than 0.39 to 12.5 mcg/ml, the growth of the following bacteria. Enterobacteriaceae ; Shigella, Salmonella, Escherichia coli, Klebsiella. Gramnegative bacteria ; Vibrio cholera, V. parahemolyticus. Gram-positive cocci ; Staphylococcus aureus, group A Streptococcus. Anaerobic bacteria ; Clostridium welchii. The MIC of this drug against Pseudomonas and Proteus was 100 mcg/ml. From the antibacterial spectrum of this drug, it was considered that the antibacterial activities of nitroimidazole thiadiazole were equivalent to those of known antibiotics used as controls. Of the known antibiotics compared with this drug, tetracycline revealed the closest antibacterial spectrum to this drug. Against Shigella and group A Streptococcus, antibacterial activities of this drug were superior to those of tetracycline. Against other bacteria, antibacterial activities of these two drugs were the same.