1) The combination of SMX and TMP in the four experimental infections of mice proved more effective than either SMX or TMP alone. Especially in combinations of SMX and TMP in the proportion of 2+1 and 5+1 are proved synergistic in these four experimental infections.
2) When tested against sulfamethoxazole resistant strain of Escherichia coli, 2+1 combination showed a synergistic effect.
3) The synergistic effects were similary observed both on the experimental sepsis and on the experimental foot-pads infections caused by Klebsiella pneumoniae in mice.
