The anti-microbacterial activity of the combination of sulfamethoxazole (SMX) and trimethoprim (TMP) combined in a ratio of 20 : 1 was studied in 20 strains of Staphylococcus aureus, 20 strains of Escherichia coli, 10 strains of Proteus, 9 strains of Klebsiella and 4 strains of Pseudomonas aeruginosa. All strains of Staphylococcus aureus, Escherichia coli, Proteus and Klebsiella were found to be sensitive to the combination. Pseudomonas strains were found to be all resistant to the combination, however, FIC indices were less than 1 in practically all of these strains demonstrating a potentiation of activities by the combination.
A clinical efficacy of SMX-TMP combination product was assessed in total of 26 patients with superficial infections of the soft tissues. The results were classified as markedly effective in 1, effective in 17, ineffective in 7 and undetermined in 1 : an effective rate of 72%. Anorexia and drug eruption were observed in a single patient, respectively. Another patient manifested some increase in preexisting anemic finding, which was thought to be possibly related to the medication.
