A total of 55 bacterial strains freshly isolated from clinical materials were investigated as to their sensitivity to sulfamethoxazole (SMX), trimethoprim (TMP) and their 5 : 1 combination mixture. The tested organisms comprised 11 strains of Staphylococcus aureus and Proteus, respectively, 18 strains of Escherichia coli, 5 strains of Klebsiella and 10 strains of Pseudomonas. The SMX-TMP combination was highly active against Staphylococcus aureus, Escherichia coli, Proteus and Klebsiella; the activity was potentiated by the combination.
A total of 24 patients mainly with surgical soft tissue infections has been treated with SMX-TMP combination preparation. The response was classified as markedly effective in 12, effective in 9, fair in 1 and ineffective in 2; an effective rate of 87. 5%. No significant untoward reactions have been encountered.
