1) The MIC of SF-837 was examined on 23 strains of Staphylococcus aureus derived from lesions. The peak showed 3.13 mcg/ml, and there were 2 resistant strains as >100 mcg/ml. In comparsion with the MIC of other drugs of the same family, that of SF-837 was nearly equal to those of LM and JM, though it was slightly inferior to that of EM. The cross resistance was observed among macrolide drugs, and there encountered SF-837 sensitive strains in a part of EM resistant bacteria.
2) SF-837 was administered orally once at a dose of 400 mg to 2 healthy adults, and the blood concentration showed the peak of 1.9-0.85 mcg/ml after 2 hours, and higher blood levels were maintained even after 6 hours. As for the rate of excretion in urine, 3.15-2.73% was recovered within 12 hours.
3) SF-837 was administered orally for 3-8 days ata dose of 1, 200 mg per day to 18 cases of superficial infection, and the results obtained were remarkably effective in 3cases, effective in 6 cases, slightly effective in 7 cases, and ineffective in 2 cases.,
4) As for the side-effect of SF-837, no digestive disorder was experienced as well as eruption, and no abnormal finding was observed throughout the cases of which were performed the tests on hepatic functions, renal functions and hepatologic items.
