Amoxycillinにかんする基礎的臨床的研究

抄録

1) Antibacterial activity : Staph. aureus strains showed quite similar M. I. C. of amoxycillin (AMPC) to those of ABPC, i. e. higher than those of PC G, MPIPC or nafcillin. AMPC and ABPC showed similar activities (M. I. C. ≤25 mcg/ml) against E. coli and Proteus strains.
2) Blood levels and urinary excretion : Cross over tests using four volunteers revealed that oral administration of 250 mg AMPC gives rather higher blood levels than that of 500 mg ABPC. Urinary recovery rate of AMPC was higher than that of ABPC; amounts recovered from urine after 250 mg dosage of AMPC were often larger than those after 500 mg dosage of ABPC.
3) Clinical trials : Twelve cases of respiratory tract infections (bronchopneumonia 3, bronchitis 5, bronchitis with pharyngitis 1, and tonsillitis 3) as well as one case of pyelonephritis were treated with AMPC (mostly 1 g/day, 4-23 days). Eight of the cases responded with good results, four with fair results, although one of them showed no response to the treatment.
The results obtained suggest the usefulness of the drug, especially for the treatment of the gram-negative bacilli infections.