Amoxycillin (α-Amino-p-Hydroxybenzyl Penicillin, BRL 2333) の小児における吸収排泄と臨床投与成績

抄録

Amoxycillin (α-amino-p-hydroxybenzyl penicillin) is a new semi-synthetic penicillin with a broad spectrum of antibacterial activity similar to that of ampicillin.
From the fundamental and clinical studies on amoxycillin in the pediatric field, the following results were obtained.
1) In three children, the highest blood level after single oral dose of amoxycillin of 250 mg averaged 2.52 mcg/ml in two hours after administration, and the blood level in 6 hours after administration was 0.06 mcg/ml. Cumulative urinary excretion in three cases was 80.0%, 59.4% and 46.7% of the given dose in 8 hours after administration, respectively.
2) Amoxycillin was administered to 20 children with various bacterial infections and found to be effective in 16 cases of them.
3) No particular side effects were observed.