泌尿器科領域におけるAmoxycillin (α-Amino-p-hydroxybenzyl penicillin) の基礎的・臨床的検討
1973 年 21 巻 8 号 p. 1716-1722
詳細
1973 年 21 巻 8 号 p. 1716-1722
Laboratory and clinical investigations were performed on a new penicillin for oral dose, amoxycillin.
1. Antibacterial activity
Antibacterial activity of amoxycillin was compared with that of ampicillin on 11 strains preserved in our Department and 109 strains isolated from urinary tract infections, and the MIC was presented to be equal or 1 tube lower. As to the strains isolated from patients, both gram-negative and-positive bacteria were inhibited the growth at a lower concentration of the drug.
2. Blood serum concentration
Blood serum concentration was measured after 250 mg of amoxycillin or 250 mg of ampicillin were administered orally singly after a meal and after 150 ml of water were drunk after the administration. The blood serum concentration was higher when the water was drunk after an oral administration of amoxycillin than when the antibiotic was administered singly.
3. Clinical result
Effective ratio demonstrated 76.5% in simple inflammation and 33.3% in complicated inflammation respectively with amoxycillin. As for the side effect of the antibiotic, no remarkable change was found objectively, except a drug rash was noticed only in 1 case.
