EVALUATION OF ABNORMAL SERUM TRANSAMINASE LEVELS WITH CARBENICILLIN ADMINISTRATION
1974 Volume 22 Issue 3 Pages 243-246
Details
1974 Volume 22 Issue 3 Pages 243-246
Serum transaminase (GOT & GPT) and creatinine phosphokinase (CPK) levels during carbenicillin administration were determined after urological surgery.
Carbenicillin was administrated intravenously at a daily dose of 4 g. The slight elevations of GOT were observed in 14 out of 49 cases during carbenicillin therapy. Abnormal levels of GOT were transient without any sign of liver damage.
A good relationship was obtained between GOT and CPK in the most cases (11 of 13), but a few (2 of 13) did not show any abnormal CPK levels with high GOT levels.
It therefore follows that there are two types of abnormal GOT elevation with carbenicillin administration. One is transient GOT elevation with high CPK levels, and the other is an abnormal liberation of GOT from hepatic cells.
