A LONG TERM INTERMITTENT GENTAMICIN THERAPY IN A PATIENT WITH FREQUENTLY RELAPSING PYELONEPHRITIS DUE TO PSEUDOMONAS AERUGINOSA
1974 Volume 22 Issue 3 Pages 258-263
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1974 Volume 22 Issue 3 Pages 258-263
A 6-month course of intermittent gentamicin therapy resulted in eradication of bacteriuria in a patient with frequently relapsing pyelonephritis due to Pseudomonas aeruginosa in 22 years.
The causative organism isolated was not susceptible to chemotherapeutic agents except gentamicin and colistin. In spite of his severely impaired renal function, gentamicin was given intramuscularly at a dose of 40 mg every 24 hours for first 10 days, and then the administration interval was prolonged to every 48 hours based on serum level and urinary concentration of gentamicin. The total dose of gentamicin amounted to 3, 840 mg without any side effects during this course. Bacteriuria was completely eradicated and no relapse occurred at least in 18 months after the treatment.
It was proved that even in the patient with severe renal impairment, a long term gentamicin therapy was possible when dosage modification was carefully monitored by serial determination of serum level and urinary concentration of gentamicin with scrupulous attention to side effects.
