EFFECT OF HUMAN PLACENTAL LYSOZYME AGAINST CLOSTRIDIUM TETANI

Abstract

Antibacterial action of human placental lysozyme against Clostridium tetani in vitro was studied as well as protective effect of the lysozyme alone in combination with anti-toxin on experimental toxicosis in mice induced by tetanus toxin.
(1) Lysozyme added to anti-toxin and complement in vitro, no enforcing effect was observed on the activity of anti-toxin and complement against Clostridium tetani.
(2) The lysozyme revealed a remarkable action of toxin release from cells without killing the microbes.
(3) A remarkable reinforcing effect of lysozyme was noted on neutralization of toxin with anti-toxin.