マウスの実験的サルモネラ症に対するNitrofuran剤および常用抗生剤の治療効果の比較検討

抄録

Comparative studies were made on the therapeutic effects of several antimicrobial agents, such as Panfuran-S (FT), Chloramphenicol (CP), Kanamycin (KM), Aminobenzylpenicillin (ABPC) and Cephaloridine (CER), for experimental salmonellosis in mice infected with an avirulent variant strain of Salmonella enteritidis, RB₁.
Of them, FT was found to have the most significant therapeutic effect (P<0.01-0.05), when more than 0.5 mg of the drug per mouse once a day was administrated orally at 0 and 24 hours after the infection. KM exhibiting the effect next to FT was effective only when it was administratedvia the intramuscular route immediately after infection, however, it was no longer effective if it was administrated 24 hours after the infection. None of the CER, ABPC and CP showed therapeutic effect on experimental salmonellosis in mice.