The present authors have carried out the laboratory and clinical studies of cephradine, and the results were obtained as follows :
The drug sensitivity was measured by a plate dilution method on 31 strains of Staph. aureus and 22, strains of E. coli both isolated from patients.
The growth of Staph. aureus was inhibited in 87. 0% at a concentration of less than 6. 25 μg/ml of the drug, while that of E, coli was in 71. 0% at a concentration of less than 25. 0 pg/ml of the drug.
Cephradine dry syrup was given orally once at a dose of 25. 0 mg per kg of body weight to 2 children. The blood level of the drug reached the maximum of 18. 5 μg/ml 1 hour after the administration, whereas it was not determined 4 hours after the administration.
Cephradine dry syrup was effective clinically in 7 out of 9 cases of pediatric infections.
As a side effect with the drug, eosinophilia occurred in 2 patients and diarrhoea in 1 respectively.
