Carfecillinに関する臨床的研究

抄録

Serum concentration of carbenicillin was determined after carfecillin was administered orally once at a dose of 1g in 4 patients of severe renal dysfunction (on or off hemodyalysis) and 2 patients of pyelonephritis.
As to the former patients, peak concentration in serum was 8.3μg/ml on an average in patients on hemodyalysis and 12.4 μg/ml on an average in patients off hemodyalysis respectively 4 hours after administration, and level decreased gradually to 1.8 and 2.7 μg/ml respectively after 24 hours. Urinary recovery rate in those patients was only less than 0.8 % at maximum within 24 hours.
As to the latter patients, serum concentration reached a peak of 7.9 and 4.4μg/ml respectively at 1 hour in patients of subchronic and chronic pyelonephritis in whom GFR was 154 and 97 ml/min. Urinary concentration showed 290 and 260μg/ml, and recovery rate was 7 and 9 % respectively within 6 hours.
In clinical trial of 11 cases with urinary tract infection, carfecillin treatment with a daily dose of 2-4 g resulted in remarkable effect in 2 cases, good in 7 cases and poor in 2 cases.
As for side effect, renal function, liver function and blood chemistry were examined, setting apart 2 patients with renal insufficiency in whom tests on renal function were omitted, as their values would have been fluctuated by hemodyalysis. Eosinophil count was elevated slightly in 4 cases, and yet no skin rash nor liver dysfunction were noticed there. Other side effects, such as gastro-intestinal disorder and skin rash, were not observed throughout the clinical studies.