Pipemidic acid の in vitro 抗菌作用
1975 年 23 巻 9 号 p. 2635-2639
詳細
1975 年 23 巻 9 号 p. 2635-2639
Sensitivity of various clinical isolates to pipemidic acid, a new synthetic antibacterial agent developed at Research Laboratories, Dainippon Pharmaceutical Co., Ltd., was examined in vitro with the following results.
1. Pipemidic acid showed potent antibacterial activity primarily against gram-negative bacteria.
2. The MIC values of pipemidic acid for Pseudomonas aeruginosa ranged around 12.5 μg/ml, and those for nalidixic acid-resistant bacteria around 25 μg/ml.
3. Most of the strains of Escherichia coli and Klebsiella sp. were inhibited by 3.13 μg of pipemidic acid per ml or lower, but a few Klebsiella strains required 25 μg of the drug per ml to be inhibited.
