Pipemidic acidの毒性学的研究

第1報 マウス, ラット, イヌおよびサルにおける急性毒性試験

抄録

The acute toxicity of pipemidic acid (PPA) was examined in mice, rats, dogs, monkeys and neonatal rats with following results.
animal route sex LD₅₀ (mg/kg)
mouse i. v. male 610
female 649
s. c. male 1, 274
female 1, 516
p. o. male >5, 000
female >5, 000
animal route sex LD₅₀ (mg/kg)
rat i. v. male 575
female 584
s. c. male 1, 635
female 1, 799
p. o. male >5, 000
female >5, 000
animal route sex LD₅₀ (mg/kg)
dog p. o. male >2, 000
female >2, 000
monkey p. o. male >2, 000
female >2, 000
neonatal p. o. male 1, 597
rat female 2, 156
Intravenous administration of PPA near the mean lethal doses caused tonic convulsion, mydriasis, ataxia, muscle relaxation, a decrease in spontaneous locomotion and interrupted respiration.
Subcutaneous administration of PPA near the mean lethal doses also induced sedation, ataxia, ptosis, a decrease in spontaneous locomotion, a drop in body temperature, paralysis of respiration, etc. On the other hand, oral administration of PPA did not cause any toxic signs even at high doses in all the animals examined except for a slight decrease in the body weight gain of neonatal rats.
It seems that there is no significant difference between animal species or sexes in the acute toxicity of PPA.