Pipemidic acidの研究
1975 年 23 巻 9 号 p. 2771-2776
詳細
1975 年 23 巻 9 号 p. 2771-2776
The MICs of pipemidic acid against 12 strains of Escherichia coli and 8 strains of Pseudomonas aeruginosa isolated from patients were lower than those of nalidixic acid and piromidic acid as determined by the plate dilution method.
Concentrations of the drug were determined in serum and urine of 3 normal volunteers after oral administration of 1g. The mean peak concentration in serum was 5. 8μg/ml after 2 hours and the mean urinary recovery rate was 52. 6% in 6 hours.
Twenty five courses of the therapy in 22 patients with infectious diseases (8 of acute cystitis, 6 of acute pyelonephritis, 4 of acute cholecystitis, etc.) were treated with 1.0 to 2.0g of the drug per day for 5 to 14 days.
These diseases were found to be caused by E. coli in 14 cases, by Klebsiella in 5, by Citrobacter in 3 and so on. Therapy with the drug resulted in cure in 15 of 25 courses, whereas infection was persistent in 6 courses.
Superinfection occurred in 2 courses and relapse in 2 courses.
As to the side effect of the drug, epigastric discomfort and fullness feeling were observed in 1 patient.
