Pipemidic acidの基礎的, 臨床的検討
1975 年 23 巻 9 号 p. 2792-2797
詳細
1975 年 23 巻 9 号 p. 2792-2797
Laboratory and clinical studies on a new synthetic chemotherapeutic agent, pipemidic acid, were performed with the results which summarized as follows :
1) In a study by the agar plate dilution method on a total of 89 strains of 9 species, E. coli (23 of 24 strains), Klebsiella (11 of 11 strains), E. aerogenes (7 of 7 strains), E. cloacae (2 of 2 strains), Proteus group (6 of 6 strains) were found to be sensitive to the agent with the MICs of 25 pg/ml or less. Staphylococcus aureus strains were less sensitive with the MICs more than 50 μg/ml. MICs to Pseudomonas aeruginosa were distributed from 100 μg/ml to 3.12 μg/ml, then 13 of 18 strains were fairly sensitive with the MICs of 25 μg/ml or less.
2) All of 40 strains of Yersinia enterocolitica and 19 strains of Yersinia pseudotuberculosis including isolates from men or domestic animals and reference strains were found to be sensitive with the MICs of 6.25 μg/ml or less.
3) By the thin-layer cylinder-plate method using Sh. flexneri 3a 5184, as the test organism, active concentration in body fluids was assayable to the lower limit of 0.1 μg/ml.
Following a single oral administration of 500 mg pipemidic acid, the blood peak levels of 2.8-4.4 μg/ml were observed at 1-4 hours. On these occasions, urinary peak levels were 520-540 μg/ml and urinary recoveries were 40.0-40.9%
4) Pipemidic acid was administered in 2 cases of urinary tract infection and was effective clinically and bacteriologically in both cases. And no side effect was noted.
