On 8 cases of respiratory tract infections due to Pseudomonas aeruginosa, 1 case of acute bronchiolpneumonia was markedly improved by administration of pipemidic acid (PPA) and 1 case of chronic bronchitis was significantly improved. The other 6 cases did not respond to this drug. As the case of acute bronchiolpneumonia successfully treated with PPA had previously failed to respond to sulbenicillin, gentamicin and colistin, PPA seemed to have a clinical meaning to be appreciated.
PPA administration was discontinued in 1 case due to such side effect as fever and headache but no abnormality was observed in biochemical tests.
It is considered that PPA is a useful drug for respiratory tract infections due to Pseudomonas aeruginosa though its application seems to be limited to diseases other than diffuse panbronchiolitis.
