1975 年 23 巻 9 号 p. 2918-2923
Fundamental and clinical studies on pipemidic acid were investigated, and the following results were obtained.
(1) Antibacterial activity
The sensitivity of PPA and NA was examined in Staphylococcus aureus and gram-negative bacteria. In comparison with NA it was effective to gram-negative bacteria, whilst it was slightly ineffective to Staphylococcus aureus.
(2) Absorption and excretion
PPA (1g) was administered once at fasting in 3 healthy adults, and blood level and urinary excretion were examined. Peak blood level on average was 6.5μg/ml at 1 hour and recovery from urine within 8 hours was 33.7%.
Biliary excretion was measured in 3 clinical cases. PPA was excreted well in bile in spite of the presence of abnormality in hepatic function.
(3) PPA was administered to 2 patients with surgical infections and no particular side effects were observed.