Studies on pipemidic acid (PPA) were carried out in our clinic.
The results were as follows ;
1. The serum level of PPA, following the oral administration of 500 mg of PPA, was determined by the cup-plate method, using E. coli Kp as a test organism. The serum level was 1.7 μg/ml at 30 minutes, 3.3 μg/ml at 1 hour and 1.3 μg/ml at 6 hours after the administration.
2. Urinary excretion of PPA was also determined by the same method, and 27 % of the administered dose was recovered in urine within 12 hours after a single dose of 500 mg per os.
3. The transfer of PPA from mother to fetus was examined in 6 cases of normal pregnant women. The levels of PPA in umbilical cord blood and in amniotic fluid were extremely low.
4. PPA was effective in 29 of 35 cases in our clinic, including urinary tract and pelvic infections.
5. In one case, drug eruption appeared. One complained of epigastralgia and the other had diarrhea. No other side effects nor adverse reactions were found in other cases.
