1975 年 23 巻 9 号 p. 2980-2982
Pipemidic acid (PPA) was administered to 11 cases of acute simple urinary tract infections at a daily dose of 750 mg for 7 days and its effect was excellent in all cases. When the drug was administered to 9 cases of chronic complicated urinary tract infections at a daily dose of 750 mg or 1, 000 mg for 14 days, the results were excellent in 1 case, effective in 2 and ineffective in 6.
The sensitivity of organisms isolated from urine to PPA was closely correlated with the clinical effect of the drug in acute urinary tract infections, while it was not in chronic urinary tract infections possibly due to host factors interrupting a cure.
No side effects were observed in subjective symptoms and blood biochemical analysis in 20 cases treated with PPA.