Abstract
Pipemidic acid (PPA) was orally administered to 21 cases of various urinary tract infections at daily doses of 750-3, 000 mg for days and the following results were obtained.
1) The efficacy rates of PPA were 100% (excellent ; 7 cases, effective ; 1 case) in acute simple cystitis, 100% (excellent ; 2 cases, effective ; 2 cases) in chronic simple urinary tract infections, and 55.6% (effective ; 5 cases, ineffective ; 4 cases) in chronic complicated urinary tract infections.
The total efficacy rate was 80.9% (excellent ; 9 cases, effective ; 8 cases, ineffective ; 4 cases) in 21 cases treated.
2) Efficacy of PPA was excellent in the infections due to E. coli as well as Klebsiella sp.
3) The MICs of PPA were determined in 78 strains isolated from patients suffering from urinary tract infections. Most strains (89.4%) ofE. coliwere inhibited by 1.56-4.25 μg of PPA per ml, and most strains of Proteus mirabilis and Klebsiella sp. by 1.56-12.5 μg of the drug per ml. More than half of the strains of Pseudomonas aeruginosa were inhibited by 3.13-6.25 μg/ml, and the rest by 25 μg/ml.
4) Mild nausea was observed in 2 cases as side effect.
5) It is concluded from these results that PPA is an excellent chemotherapeutic for urinary tract infections especially due to gram-negative bacilli.
