尿路感染症に対する Pipemidic acid の応用
1975 年 23 巻 9 号 p. 3104-3109
詳細
1975 年 23 巻 9 号 p. 3104-3109
1) Minimal inhibitory concentrations of pipemidic acid were determined in 94 strains isolated from urinary tract infections by the plate dilution method. Many strains of E. coli and Proteus mirabilis were inhibited at the concentration of 6.25 μg/ml or lower. Some strains of Proteus vulgaris and Pseudomonas aeruginosa were inhibited at the concentration of 25 μg/ml or lower. Most strains of Staphylococcus aureus were resistant to 100 μg/ml of pipemidic acid.
2) Twenty-three cases with urinary tract infections were treated with pipemidic acid at oral doses of 750-2, 000 mg per day. Excellent or good results were obtained in 18 cases.
3) Anorexia was observed in 1 case and temporary elevation of GOT and GPT in 3 cases on laboratory findings.
