Basic and clinical examinations of Cephacetrile (CEC), a cephalosporin derivative, were performed and the following results were obtained
1. The average blood level of CEC after intramuscular administration of 1g to six patients were 11.7±2.17μg/ml 30 minutes, 12.4±0.64μg/ml one hour, 10.27±1.14μg/ml 2 hours, 4.98±1.41μg/ml 4 hours, and2.02±0.64μg/ml 6 hours.
2. The sputum levels of CEC after intramuscular administration of 1 g were 0.3μg/ml 0 to 2 hours, 0.7μg/ml 2 to 4 hours and 0.8μg/ml 4 to 6 hours.
3. The spinal fluid levels of CEC after intramuscular administration of 1g to two patients with meningitis were 0.2μg/ml and 0.3μg/ml.
4. CEC was used in 8 patients with respiratory infections, and the effectiveness was obserbed in 7 cases (85.7%). No side effects with CEC was found.
