1976 年 24 巻 1 号 p. 333-340
Nine-teen cases with urogenital infections and 4 cases for prophylaxis of postoperative infections were given Cephacetrile (CEC) at a daily dose of 4-6g except one case of child given 2g daily for 4 to 7 days intravenously by dripinfusion.
Of 10 cases with acute pyelonephritis, excellent responses were seen in 5 cases, good in 3 cases and poor in 2 cases.
Of 7 cases with chronic pyelonephritis, 3 were excellent, 2 were good, 2 were poor. Of 2 cases with acute prostatitis, one was good and one was poor. Of 4 cases for prophylaxis of postoperative infection, 1 was excellent, 2 were good, and one was poor.
The antibacterial activity of CEC against E. coli, Klebsiella, Proteus, Pseudomonas was almost the same as that of Cephalothin, but lower than Cefazolin.
Side-effect was experienced with CEC in one case in whom S-GOT and S-GPT elavated slightly.