最近臨床材料より分離した各種病原細菌に対するCephacetrileと他cephalosporin剤の抗菌力の比較

抄録

We determined the antibacterial activity of Cephacetrile, Cephalothin, Cephaloridine and Cephapirin against many strains of following various pathogenic bacteria by agar plate dilution method. We used 1, 105 strains of staphylococci, pneumococci, haemolytic streptococci, enterococci, 10 species of Enterobacteriaceae, Pseudomonas aeruginosa and 3 genera of anaerobes isolated from clinical materials in our laboratory during 1973 and the first half of 1974.
We examined and compared the antibacterial activity of Cephacetrile, Cephalothin and Cephaloridine against 1, 105 strains, but for Cephapirin we examined rather few strains of several species of pathogens.
1) For staphylococci, pneumococci and hemolytic streptococci was Cephacetrile least active among cephalosporins tested.
2) Cephalosporins were active to enterococci and Cephacetrile had almost same activity as Cephaloridine, but was less active than Cephalothin.
3) Among the bacteria of Enterobacteriaceae cephalosporins were less active to Enterobacter, Serratia, Citrobacter, Proteus morganii, Proteus rettgeri, Proteus vulgaris and Proteus inconstans excluding E. coli, Klebsiella and Proteus mirabilis. We could not find out the differences of antibacterial activity against E. coli, Klebsiella and Proteus mirabilis among Cephacetrile, Cephalothin and Cephaloridine.
4) Cephalosporins had not the antibacterial activity against Pseudomonas aeruginosa.
5) Cephalosporins have rather good antibacterial activity against Peptococcus, but have very weak activity against Fusobacterium and Bacteroides. Cephacetrile, Cephalothin and Cephaloridine have almost similar antibacterial activity against these three genera of anaerobes.