BACTERIOLOGICAL STUDIES ON THE COMBINED ACTION OF SYNTHETIC PENICILLINS AND POLYMYXIN-B AGAINST PSEUDOMONAS AERUGINOSA

Abstract

The synergic actions of CBPC, SBPC and PL-B were observed on Pseudomonas aeruginosa No. 12 by-Chequer board titration method.
In either case of the combination of CBPC with PL-B, SBPC with PL-B, the simultaneous administration showed the highest bactericidal effect, followed by the case of addition of PL-B after adding CBPC or SBPC, while the reverse case showed the similar effect to that of each drug alone.
The therapeutic experiment of infection demonstrated that the combination of SBPC with PL-B showed., superior effects to those of each drug alone. In comparison to this, the combination of SBPC with PL-B revealed more favorable effect by the simultaneous administration in 2 hours after infection.