EFFECT OF ORAL ADMINISTRATION OF A MOLD PROTEASE (ONOPROSE SA) ON THE CONCENTRATION OF ANTIBIOTICS IN RAT BRONCHIAL WASH

Abstract

Oral administration of a mold protease, Onoprose SA before intramuscular administration of penicillin G, aminobenzyl penicillin or cefazolin to rats. significantly increased the concentrations of these antibiotics in the bronchial wash. Other proteases. such as Bromelin and Serratia peptidase had similar effects. The effect of Onoprose SA was greater in rats with fat embolism in the lungs than in normal rats.
These results indicate that Onoprose SA stimulates the appearance of antibiotics in normal and diseased respiratory tracts and alveoli.