METABOLITES OF PIVMECILLINAM IN HUMAN URINE
1977 Volume 25 Issue 1 Pages 123-126
Details
1977 Volume 25 Issue 1 Pages 123-126
Pivmecillinam metabolites and their excretion rate in human urine were studied in the two volunteers. After administration of tablets of pivmecillinam containing 500 mg as mecillinam to man, the urine up to 6 hours were collected for every 2 hours and analysed by liquid chromatography, gas chromatography and TLC-fluorodensitometry. The following resultsl were obtained.
The principal metabolite in the human urine was mecillinam, and minor quantities of BB-511, BB-517 and HIS-1201 were also detected as the metabolites from the penicilline structure. Total recoveries of administered dose for the two volunteers were approximately 60 and 40%, respectively, and found relatively lower excretion rate of the minor metabolites to mecillinam than that in the case of rat.
As for the metabolites from the side chains, hexamethylenimine and pivalic acid were detected.
