1977 Volume 25 Issue 1 Pages 317-322
Pivmecillinam is a unique antibiotic of which metabolic derivative, mecillinam, is highly sensitive to gram negative bacteria such as E. coli and Klebsiella. Sensitivity distribution of pivmecillinam and mecillinam to 65 strains of E. coli isolated from UTI patients showed sensitivity peak at 1.56 μg/ml. and 0.39 μg/ ml. Peak serum level reached to 1.04 μg/ml 2 hours after oral administration of pivmecillinam 100 mg in2 healthy adults under non-fasting condition. The urinary recovery rate up to 8 hours was 47.1% and urinary concentration higher than 100 μg/ml continued for 6 hours after the administration.
Pivmecillinam 200 mg q.i.d was given to 30 cases of acute simple cystitis for 3 to 7 days. Bacterial and clinical response were obtained at 90% and 96.7% respectively. Pivmecillinam 600 mg t.i.d was given to 8 cases of chronic complicated cystitis. of 8, eradication of bacteria in a case and decrease of bacterial counts in the urine in 2 cases were observed No unfavourable side effect was noticed.
