医原的要因に伴う感染症と分泌型IgA
免疫抑制因子の及ぼす影響
1977 年 25 巻 10 号 p. 2993-2999
詳細
1977 年 25 巻 10 号 p. 2993-2999
IgA system with special reference to secretory IgA was studied on the patients treated with immunosuppressive agents. And the relationship between the occurrence of infection and secretory IgA level was discussed in this paper. The results were as follows.
1) Infection occurred in 9 cases out of 19 patients treated with immunosuppressive agents.
2) Peripheral neutrophil and lymphocyte counts were decreased significantly by immunosuppressive treatments. The frequency of infection increased as peripheral neutrophil counts decreased.
3) In the pre-treated patients, serum IgA and IgG levels were significantly higher than those of normal adults. High levels of them may be due to the primary diseases. The effects of immuno-suppressive treatments on serum IgA, M and G were not clear.
Secretory (salivary) IgA levels from the patients treated with immunosuppressive agents were also significantly higher than those of normal adults. This high level of S-IgA was thought to be caused. by primary diseases. In spite of immunosuppressive treatments, salivary IgA levels were not decreased below normal levels. The correlation between the occurrence of infection and salivary IgA levels was not found. It was suspected that the salivary IgA levels were not so important as the peripheral neutrophil counts against infections in the secondary immunodeficient states.
