Abstract
The subacute toxicity of T-1220 was examined in rats, using the intravenous administration route, and compared with that of aminobenzylpenicillin (ABPC). Male and female rats of age 6 weeks were applied. T-1220 was administered to the rats in daily doses of 500, 1, 000 and 2, 000 mg/kg for a month and ABPC was used at 2, 000 mg/kg. Control rats were treated with physiological saline.
The results are as follows.
1) 5 out of 15 males and 7 out of 15 females given T-1220 at 2, 000 mg/kg were died because of massive hemorrhage of the lung.
2) The body weight gain was slightly depressed in rats of both sexes treated with T-1220 at 2, 000 mg/kg.
3) There were no dose-related changes of urinary examination, biochemical examinations and hematological findings in all the groups of T-1220.
4) Any abnormalities caused by the administration of T-1220 were not found in the organ weight, autopsy and histological observation.
5) The appreciable increase of urine volume and slight increase of BUN were observed in females treated with ABPC at 2, 000 mg/kg. The tubular lumina of the renal cortex was slightly dilated and the tubular epithelium had the hydropic change in the same females. There was, however, no significantly histological change in the kidneys of rats treated with T-1220.
6) The maximum safety dose of intravenous administration of T-1220 to rats seemed to be 1, 000 mg/kg.
