1977 Volume 25 Issue 8 Pages 2332-2337
Bleomycin depo was administrated 12 times to 10 patients with malignant lymphoma, including 4 cases of Hodgkin's disease, 4 reticulum cell sarcoma, 1 lymphosarcoma and 1 giant follicular lymphoma. It was also given to 4 patients with lung cancer, 1 esophagus cancer, and 1 keratoacanthosis. Eight patients with malignant lymphoma were treated with combination therapy of BLM depo, 6-mercaptopurine, cyclophosphamide, procarbazine and prednisone. Other 2 were treated with BLM depo only. Five patients with lung cancer and esophagus cancer were also treated with BLM depo only. In effective cases of malignant lymphoma, enlarged lymphnodes shrunk rapidly after administration of 15 to 45 mg of BLM depo and remission obtained in 10 of 12 cases. BLM depo was also effective in 3 of 4 patients with lung cancer but not effective for keratoacanthosis. The mean duration of remission was 4. 2 months without consolidation therapy. It was vigorously, prolonged by consolidation with VEMP therapy during remission in 4 cases. Fever developed in 6 of 17 patients. Pulmonary dysfunction, suggesting fibrosis, occurred in 2 of 17 cases but it was not fatal.
